I've been using Cloudberry for a while now and will try and answer your questions.
Right now my clients are all very small businesses. Less than 10 computers, no servers. There is one residential client who is using the service, but she is writing two books about her family and doesn't want to risk losing her research.
My Default Backup Profile
*Force Using VSS
*Paths: Desktop, Documents, Pictures
*Backup Storage: Google Cloud Platform
*Compression, but no encryption (still undecided about this one)
*Retention Policy: 3 versions
*Schedule Options: Daily, every 4 hours from 0600-2200
*Run missed scheduled backups immediately
(The above was taken straight from my dashboard)
Well, that's the default. It doesn't change much unless the user has moved stuff around or if they have QB.